Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation / (Record no. 3243)

000 -LEADER
fixed length control field 02539nma a2200325 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 2013 eng
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
ISSN 0002-9254
040 ## - CATALOGING SOURCE
Transcribing agency Sonoma County Wine Library
041 ## -
-- eng
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Takeshi Sugiyama.
245 10 - TITLE STATEMENT
Title Grape Seed Extract from Koshu Cultivar Antagonizes Dioxin-Induced Aryl Hydrocarbon Receptor Activation /
Statement of responsibility, etc by Takeshi Sugiyama.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Name of publisher, distributor, etc American Society for Enology and Viticulture,
Date of publication, distribution, etc 2013.
300 ## - PHYSICAL DESCRIPTION
Type Journal article
490 0# - JOURNAL TITLE
Title of the journal American Journal of Enology and Viticulture
520 ## - ABSTRACT
Abstract The aryl hydrocarbon receptor (AhR) pathway is now considered an important pharmacological target for many human diseases. This study examined the effects of grape seed extract (GSE) obtained from the Koshu grape variety on AhR activity. The Koshu-derived GSE inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated AhR activation in vivo and in vitro. These results suggest that Koshu GSE has an antagonistic effect on TCDD-induced AhR activation. Furthermore, gavage administration of TCDD resulted in the elevation of liver function, but administration of Koshu GSE together with TCDD did not elevate serum aspartate aminotransaminase (AST) and alanine transaminase (ALT) levels. These results suggest that Koshu GSE may have the potential to prevent liver disorders.
700 0# - ADDED ENTRY-PERSONAL NAME
PERSONAL NAME Masanori Kitamura.
700 0# - ADDED ENTRY-PERSONAL NAME
PERSONAL NAME Masashi Hisamoto.
700 0# - ADDED ENTRY-PERSONAL NAME
PERSONAL NAME Kanji Sugita.
700 0# - ADDED ENTRY-PERSONAL NAME
PERSONAL NAME Atsuhito Nakao.
700 0# - ADDED ENTRY-PERSONAL NAME
PERSONAL NAME Tohru Okuda.
710 2# - ADDED ENTRY-CORPORATE NAME
CORPORATE NAME Atopy Research Center, Juntendo University School of Medicine, Tokyo 113-8421, Japan.
710 2# - ADDED ENTRY-CORPORATE NAME
CORPORATE NAME The Institute of Enology and Viticulture, University of Yamanashi, 13-1, Kitashin 1, Kofu, Yamanashi 400-0005, Japan.
710 2# - ADDED ENTRY-CORPORATE NAME
CORPORATE NAME Department of Immunology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
710 2# - ADDED ENTRY-CORPORATE NAME
CORPORATE NAME Department of Pediatrics, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
710 2# - ADDED ENTRY-CORPORATE NAME
CORPORATE NAME Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.
773 0# - SOURCE JOURNAL
Journal title American Journal of Enology and Viticulture.
Related parts (Vol.) 64. (No.) 1. 2013. (Pages.) 146-151.
Page numbers 146-151
Volume number 64
856 42 - ELECTRONIC LOCATION & ACCESS
URI http://ajevonline.org/content/64/1/146.abstract
991 ## - OAI IDENTIFIER
OAI set code AJEV
OAI set name American Journal of Enology and Viticulture
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-- 12119
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856 42 - ELECTRONIC LOCATION & ACCESS
-- Link to original article.

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